Y3V-T2-LSN4

• Biologie
• Voortgezet speciaal onderwijs
• Leerroute 3

Welcome, please get ready:

• Pen and Paper
• Copy of the book

Disease & Immunity

Lesson 4

2nd line of defence

Lines of defence

Learning goals:

• I understand the difference in innate and adaptive immune system
• I understand the difference in specific and aspecific immune system
• I can explain what barriers in the human body contribute to immunity
• I can explain how phagocytes contribute to immunity

KEY WORDS:

• Lymphocytes
• Phagocytes
• Macrofages
• Phagocytosis
• Dendritic cells
• Neutrophils

• Innate immunity
• Adaptive immunity
• Barrier function
• Phagocyte
• Phagocytosis
• Lymphatic system
• Lymph nodes

Line 2: phagocytes

phagocytes are able to perform phagocytosis

different types of phagocytes

dendritic cells

macrophages

neutrophils

phagocytes that display parts of pathogen on there membranes for display and presentation

phagocytes that patrol in tissues and kill off pathogens. They can be controlled by lymphocytes (line 3)

phagocytes that kill off pathogens by killing themselves

Overview of line 2

Line 1 fails: pathogens invade the body

Surviving tissue cells call for help

Macrophages start to devour pathogens and send out signs

Neutrophils arrive and join the battle. They massively kill off the pathogens and themselves

Proteins of the complement system start to kill pathogens by perforating them

Dendritic cells display parts of the pathogens on their membranes and travel to the lymph nodes

Activation of defence line 3: the adaptive immune system - the lymphocytes

Inflammation

a reaction from the tissue to the signaling molecules

Lymphatic system

lymph vessels, lymph nodes, bone marrow, spleen and thymus

sewage system of your body

drained tissue fluid is sent to lymph nodes for screening

here the dendritic cell presents its pathogen parts (antigens)

Learning goals

• I understand the difference in innate and adaptive immune system
• I understand the difference in specific and aspecific immune system
• I can explain what barriers in the human body contribute to immunity
• I can explain how phagocytes contribute to immunity

Keywords

Innate immunity

Adaptive immunity

Barrier function

Phagocyte

Phagocytosis

Lymphatic system

Lymph nodes

A concept map

A concept map adds descriptions to links between two terms

Homework for next lesson:

• Create a concept map on the INNATE IMMUNE SYSTEM of the human body.
• Hand it in on the google class room before the start of next lesson

Note the names of the different types of phagocytes that play a part in your innate immunity

1

2

3

Surviving tissue cells are sending out distress molecules

macrophages respond and start to devour the pathogens. They also send out other alarm molecules

neutrophils respond and leave the blood vessels. They attack the pathogen by releasing toxic molecules and they kill themselves off

Inflammation causes a lot of discomfort. Still it is very useful: for what purpose does tissue get inflamed?

What is the main 'ingredient' of pus?

1. pathogens
2. macrophages
3. neutrophils