While Sam's very good at languages, his brother is absolutely hopeless.=
Sam's very good at languages, at the same time his brother is absolutely hopeless.
Despite being very hard-working and punctual, he couldn't finish his essay in time.
In spite of being very hard-working and punctual, he couldn't finish his essay in time.
Even though Dylan was one of the professor's favourite students, he failed the exam.
I'll get there, even if I have to walk.